South America is the vast continent of land to the south of North America, on the planet Earth.
After stealing Bumblebee's T-cog, MECH retired to a base in South America to attempt to use it. With Starscream's help, MECH almost got their robot working, but Bumblebee arrived and reclaimed his cog. Silas promptly had Starscream's cog stolen, grounding the Decepticon.
After an abortive attempt on her life, Airachnid found an Insecticon and lured Megatron to an old energon mine to fight it. Though the plan failed, Airachnid stumbled on a whole hive of Insecticons.