Omega Supreme is the mightiest Cybertronian warrior of all Autobots, striking fear into the Decepticons' Sparks with his massive firepower and his starship alt-mode. He is known to be the Autobots' last line of defense during the Great War. His greatest enemy is Trypticon.
Omega Supreme was the guardian of the Omega Gate, which gave access to the Core of Cybertron. Omega lay inactive during the war until Megatron's forces invaded Iacon seeking what they thought was the Omega Key, which would allow access to the Core, forcing Sentinel Zeta Prime to activate the false Omega Key and awaken the sleeping giant. The giant Autobot's mission: Destroy Megatron.
Omega followed the homing signal of the false Key and destroyed the fleet of Decepticon ships Megatron was using to search for him. As the Decepticons were securing their wounded, the mighty Autobot attacked, destroying their rescue ship and killing the survivors. At first, the Decepticons seemingly defeated the Guardian of Iacon when they destroyed the supports for a section of bridge Omega was standing upon, but the Autobot returned with a vengeance, using his main gun to disintegrate what remained of the bridge and forcing Megatron's squad to flee to safety.
Omega Supreme attacked Megatron wherever he went, destroying a cargo lift the Decepticon rode, smashing his way through a tunnel and laying landmines upon a bridge that was the only route to safety. Eventually, Omega Supreme tracked the Decepticons to an Autobot anti-aircraft battery on a terrace and attacked with his main gun, heatseeking missiles, the Aerialbots and briefly defending himself with an impenetrable Energon barrier. However, the Decepticons discerned the pattern of Omega's attacks and breached his armour thanks to the terrace's turrets, forcing him to crash down into a sub-level of Iacon below.
Sure that the Autobot was destroyed and eager to get his hands on the means to open the Omega Gate, Megatron led his squad down, only to find that Omega Supreme had transformed and re-energized himself with Energon batteries drawn from underground. Omega Supreme battered the Decepticons with a combination of missiles, laser turrets, his main gun and a powerful arm-mounted tractor beam, until Soundwave deduced that Omega's defensive weakness were his turrets - destroying them forced the Autobot guardian to draw upon the Energon batteries to regenerate.
Seizing the advantage, the Decepticons infected the batteries with a charge of Dark Energon, corrupting Omega Supreme's systems when he drained the batteries. While Omega dealt with the Dark Energon with a counter-virus, Megatron attacked, severely damaging the Autobot's armor. Down but not out, Omega Supreme drew energy from Cybertron's core itself and unleashed a withering multitude of missiles upon the Decepticons. However, with his internal shielding exposed, Omega was vulnerable, and eventually the Decepticons brought him down by blasting his exposed chest cavity. Gloating in victory, Megatron blasted Dark Energon into Omega Supreme's chest, and the Autobot, helpless to fight against it, was corrupted. Omega Supreme was taken underground where he was forced to open the Omega Gate, allowing Megatron to corrupt Cybertron's core with Dark Energon.
The rumours of Omega Supreme and Zeta Prime's defeats spread through the Autobot camp, leaving the Autobots direction-less and dispirited. Just when hoped seemed to die for the Autobots, a new hero stepped up to lead them: Optimus Prime, the last of the Primes.
Charged by the Autobot High Council with destroying the infection to Cybertron's core, Optimus Prime lead a team consisting of Ironhide and Warpath to the chamber outside the Omega Gate, where Omega Supreme was imprisoned. There they found the Decepticons torturing the giant Autobot and force-feeding him Dark Energon to prevent him from repairing himself and escaping his bonds. After his captors were destroyed, Ratchet began repairing Omega Supreme's damage and Dark Energon corruption, but the party were set upon by dozens of Decepticon reinforcements. Just as they were attacked by a Decepticon Destroyer, Omega Supreme regained enough functionality to rip the foes to pieces with one hand.
With the present Decepticon threat removed, Omega Supreme opened the Omega Gate to Cybertron's core. However, his systems were not yet fully operational; repairs would have to be completed at Autobot headquarters while Optimus and his team headed down into the depths of Cybertron.
Perceptor revealed in a datalog that Omega Supreme carried on his duty as guardian of the Core and Iacon fiercely defending both of them until his final confrontation with Megatron, which ended with Dark Energon being poured into him again. This caused him to fall into a complete stasis lock.
Omega Supreme was the legendary Guardian of Crystal City. Having acquired the Code Keys of Power and Justice, Megatron opened the entrance to the Plasma Energy Chamber below the High Council Tower to corrupt the Core of Cybertron with Dark Energon. Teletraan-1 reactivated Omega Supreme to fly the Plasma Energy Chamber to safety. Omega was horrified to be informed by the Communication Grid that the Decepticons held eighty-five percent of the planet; that only three of the High Council lived and all of them were Decepticons; the AllSpark had been ejected from the Well of All Sparks; and Sentinel Prime was dying. He informed Optimus Prime he should have reactivated him sooner, though they had no idea he even existed, and Omega acknowledged it was because of Optimus that the Autobots held out for so long.
Omega tried to fly into space, where Teletraan-1 would give him instructions as to where to hide the Chamber, but Starscream's Seekers attacked. Omega blew up two Seekers before his own nozzles were shot at and he reverted to robot mode and fell back into Iacon. Ironhide was horrified by the Guardian's destruction but fortunately, Omega survived the impact and inspired the Autobots to fight off the Decepticons seeking to gain the Chamber. Omega killed four Dark Energon-infused Decepticons, but Megatron hammered him in the knee causing him to collapse and allowing a swarm of gladiators to crawl on him. Omega fell, crushing the gladiators, but the Dark Energon left their bodies to power Megatron to the point he could turn Omega on his back. He threatened to slice his throat, but he only wanted the Chamber, and tore it out of Omega's body before escaping.
Ratchet repaired Omega Supreme, and he was able to fight when Trypticon emerged in the Mithric Sea when the Autobots left Cybertron on the Ark. He was left with Ultra Magnus and his Wreckers to deal with Shockwave's new regime.
Ratchet repaired Omega Supreme, and he was able to fight when Trypticon emerged in the Mithric Sea when the Autobots left Cybertron on the Ark. He was left with Ultra Magnus and his Wreckers to deal with Shockwave's new regime. Exodus
After the evacuation of Cybertron and the fall of Iacon, Ultra Magnus used Omega Supreme as a mobile base of operations when the Wreckers and other pockets of Autobot resistance were forced underground by Shockwave. Omega Supreme joined Ultra Magnus, Springer, Wheeljack, Jetfire, and Rack n' Ruin on their mission to rescue Alpha Trion from Shockwave, shelling Iacon's defenses from afar and distracting Decepticon police forces long enough for the other Autobots to reach Iacon's underground levels.
During the Quintesson invasion of Cybertron, Omega Supreme was one of the first Cybertronians to stand against Tyrannicon's Sharkticon flotilla. Although the Autobot guardian brought his considerable firepower to bear, destroying several Sharkticon ships in the process, he ultimately could not stand against the general himself, who clambered up Omega Supreme and speared him through the head, taking him out of the fight.
- In the original Generation 1 series, Omega Supreme was the guardian of Crystal City which he safeguarded in collaboration with the Constructicons. Megatron's eventual brainwashing of the city's building bots had eventually led to their falling out with Omega Supreme and Devastator became Omega's mortal enemy. In the G1 series, Omega Supreme transformed into a tank, rocket, and launch bay.
- Rumors for the second half of Season 2 suggested Omega Supreme would be featured in the final episode. This was proven untrue as the Omega Lock appeared instead, but the Omega Keys showed up.