Megatron begins his insurrection during the War in a search for Dark Energon, which he believes will aid him in returning Cybertron to glory. He starts by gathering the right amount of talent to form his Decepticon army. In his optics, he is a hero.
Megatronus was once a gladiator on Cybertron, and came to believe that Cybertron was heading into oblivion. He formed a friendship with Orion Pax and gathered around him a group that were willing to follow him into a new age, including Soundwave. Upon seeing the leaders of Cybertron, he demanded to be named a Prime so that he could lead Cybertron, but was refused, and Orion was chosen instead. Megatronus renamed himself Megatron and formed the Decepticons, and led an all out war against those who stood against him.
Megatron returned to Earth through the Decepticons' space bridge after three years of being in deep space, searching for an army to conquer Earth with. While Starscream showed him an impressive Energon mine, Megatron shared his desire to use the power of his recent find, Dark Energon, the blood of the universal dominator Unicron, to create an army of the undead. After initial testing with the recently deceased Cliffjumper proved somewhat successful, Megatron then started pondering how to control such mindless beasts. Despite the arrival of Optimus Prime and his Autobots, Megatron decided he was not yet ready to confront his old friend, and ordered Starscream to destroy the mine. Later on the Nemesis, despite Starscream's protests, he placed a shard of Dark Energon inside his own Spark Chamber.
The dark substance gave him new strength, and he decided to see if he could now control the Terrorcons, heading to the corpse-filled site of an ancient battle site on Earth. Despite Optimus and Ratchet's presence, Megatron threw a second shard of Dark Energon into the ground, successfully raising an army under his control. Despite the two Autobots decimating them, Megatron revealed it was not his true plan, and flew back to the Nemesis to prepare to open a space bridge to Cybertron in order to reawaken the Cybertronian dead on the planet. However Starscream's machinations had caused his ship's interstellar navigation dish to be damaged, and while berating his second-in-command, allowed him the chance to fix the problem.
Once Soundwave had repaired the problem, Megatron engaged Optimus after he threw all of his remaining Dark Energon through the bridge to Cybertron and awoke millions of Terrorcons. During his battle, the Autobots began sabotaging the space bridge while the Terrorcons began coming towards the bridge, so Megatron waited for them, only for Starscream and the Nemesis to move away from the imminent explosion, imploring for Megatron to do the same. But he refused, and reached out for his legion as the bridge blew up, presumably killing him. Later on, Starscream, after learning from Soundwave's scans that a faint life signal was coming from the former space bridge site, found him still alive, albeit heavily damaged amongst the rubble. Wanting to take leadership of the Decepticons for himself, Starscream removed the shard of Dark Energon from his chest, which was what had allowed him to survive and prepared to leave him, only for Laserbeak to arrive on Soundwave's orders. Thus Starscream took him back to the Nemesis, where he was placed in a recovery sector.
Megatron had to stay on life support for awhile. During the time of his incapacitation, however, Bumblebee and Arcee had to find a cure for the Cybonic plague that Megatron himself had created. They found him in a lab, and Bumblebee linked his mind into Megatron, allowing him to enter Megatron's. After Bumblebee left Megatron's mind, Megatron also left and ended up in Bumblebee's mind. Megatron later took control of him to find Dark Energon to get his body active once more. He then used a ground bridge to get to his body, slammed the Dark Energon into his body and he was online once again. Then he went to deal with Starscream. Starscream, in his jet mode, was attacking an incapacitated Optimus Prime when Megatron caught him midair and threw him onto the Nemesis, revealing himself to the stunned Starscream. Realizing that his master was alive and well and knowing all of Starscream's attempts to get rid of him while he was in stasis, Starscream attempted to flee from his enraged master, but he was caught and flung back onto the Nemesis, where Megatron grabbed him by the face and dragged him screaming below deck to face his vicious punishment.
Megatron beat Starscream severely, rendering him to the table where Megatron had once laid upon, and had Knock Out take care of him to ensure he would survive other beatings. Megatron assured Starscream that their positions would never be switched. Despite being in good health, Megatron did not participate in any attempts to collect Energon or to hassle the Autobots for a while. He showed little care for Breakdown's capture from humans , and then ordering him to retrieve a polarity gauntlet in which he brought back Airachnid. .
Later, Megatron and Starscream find and enter an abandoned Decepticon mine. Starscream tries convincing Megatron that the mine truly is abandoned, but the Decepticon leader is not convinced. After traversing through the mine for a few minutes, the duo come across a large chamber filled with Decepticon mining equipment. Starscream then blurts out that the equipment should have been removed by that point, to which Megatron suggests is an excellent point. Megatron then reveals that he knew all along about Starscream's projects, and he is about to kill him, but Arcee and her human ally Jack arrive before he can. While Megatron is distracted, Starscream escapes. However, during the battle, he causes a cave-in, leaving everyone minus Starscream, who managed to escape, trapped inside. While drilling for an exit, Jack encounters Megatron, underneath tons of rubble. Megatron then escapes, and eventually comes across Starscream, holding up the ceiling of the part of the mine he is trapped in. He then begins to ponder whether he should help Starscream escape, or leave him to eventually be crushed under the cave ceiling.
As it turns out, Megatron helped Starscream to escape. Megatron then finds Airachnid, who is talking to him about a secret weapon, the Immobilizer, aboard the Harbinger, a Decepticon ship that had crash-landed on Earth. Starscream enters on them, and the two reveal to him what they were talking about. Starscream then states that he had investigated the site of the crash when the Decepticons first arrived on Earth, and when they asked if he retrieved the weapon, Airachnid mentions that the ship's site was never logged, which infuriates Megatron. Starscream then dismisses this as an oversight, and states that he has the location memorized. In response to this, Megatron assigns him and Airachnid to retrieve the weapon.
War for Cybertron game
Megatron's Decepticons are fighting the Autobots for control of Cybertron. Megatron thinks the very thing he needs to give him the edge in the War For Cybertron is Dark Energon, an extremely dangerous and powerful form of Energon. He, Barricade, and Brawl crash land their ship into the heart of the station, Megatron believing that this was the only way to get inside. Starscream confronts Megatron via hologram, telling Megatron that Dark Energon only causes death and destruction, which is exactly what Megatron wants. When Megatron, Brawl, and Barricade finally make it to the Dark Energon source, Megatron exposes himself to the Dark Energon and shows the incredible ability to control the power. Starscream is impressed and joins Megatron on the terms that he teach Starscream to control the Dark Energon and Starscream will show Megatron how to create more of the Energon.
Megatron wanted the Omega Key so that he could gain access to the core of Cybertron. Megatron, Soundwave, and Breakdown travel through Iacon to find the Omega key, only to find it in the hands of Zeta Prime. After a battle in Zeta Prime's personal vaults where Megatron must face off against Zeta's machinery and an army of Energon clones. Eventually Megatron defeats Zeta and gets what he thinks is the key, but Zeta Prime reveals that his key only activates the real Omega key, Omega Supreme.
When they go to find him, Omega attacks their ship and it crashes. Omega chases Megatron and his minions through the city and is lured to the top of a tower that has Autobot Anti-Aircraft guns. Using said guns, they attack Omega Supreme, sending him crashing to the planet's surface into a massive arena. There they battle one last time, finally breaching His armor. As Omega loses energy, Megatron takes his opportunity to infuse and corrupt him with Dark Energon. Omega is his and so is the Core.
Fall of Cybertron game
Megatron was present in the assault on the Ark in the spaceport executing a few Autobots that were prisoners with Optimus. As he was about to destroy the Ark, Metroplex came back online and mortally wounds Megatron, but the only proof that he was alive was the Dark Energon pulsing through his hand. Later, he is in Soundwave's lab where he recreated and upgraded Megatron's "already perfected" body and systems. His first time "testing" his new systems was when he goes on to ruin Starscream's coronation. Before the assault on the Ark, Shockwave noticed an odd energy signature where Trypticon fell from orbit, so Megatron went to retrieve Trypticon and enacts the "Nemesis Protocol".
- Cybertronian Megatron (Deluxe, 2010)
- Accessories: Fusion cannon, Missile
- Based on the character from Transformers: War for Cybertron, He turns into a Cybertronian tank. The spring-loaded fusion cannon is able to attach to either one of his arms. His light-piping gimmicked eyes have been painted over.
- When in vehicle mode, the treads are able to be positioned either vertically like a normal tank or horizontally in a hovertank-ish mode, referencing moments in the game where he hovers in place.
- Rage Over Cybertron Megatron (Deluxe, 2011)
- Accessories: Fusion cannon, Missile
- A repaint of Cybertronian Megatron with painted purple parts in reference to his Dark Energon powerup.
- Darkside Megatron (Deluxe, 2011)
- Accessories: Fusion cannon, Missile
- A repaint of Cybertronian Megatron in black and grey.
Prime: First Edition
- Optimus Prime vs Megatron ( first edition 5 figure gift set, 2011)
- Accessories: Fusion Cannon
A deluxe scaled version of the character.
Prime: Robots in Disguise
- Megatron (Cyberverse Commander, 2012)
- Accessories: Cyber sword
- Megatron (Voyager, 2012)
- Accessories: Cannon, Combat Claw
- He is equipped with a Fusion cannon and a Mace. He transforms into a Cybertronian tank. He also possess the ability to drain his enemies of health to refuel his own and to hover in the air for a short while.
- In Fall of Cybertron, he loses his drain ability in favor of a hover slam attack as well as having his alternate mode changed from a tank to a self propelled artillery cannon similar to the Marauders seen in the game.
- His tank mode, like all the other cons and bots with tank modes in War for Cybertron, rather than having thrusters on the bottom of craft, projects a strange electrical aura on the ground he is hovering over.
- This incarnation of Megatron resembles his Transformers Animated counterpart by his desire for Decepticon glory as well as the near-religious reverence most of his troops have for him.
- Megatron has severe contempt for his troops. At one point he witnesses a trapped Decepticon soldier crushed by Zeta Prime's machinery and his only words were "Idiot".
- In direct opposition to most other incarnations, Prime Megatron seems to be less likely to harm any of his troops (with Starscream as an exception). Thus far the harshest punishment he has given to any of his troops (who are not Starscream) are a few scolding words.
- He has a habit of screaming "For Glory!" during battle. Examples include after he has beaten a difficult enemy and after he corrupts the model of planet Cybertron in the Autobot Stellar Galleries.
- He does not believe in ghosts.
- Like Optimus Prime, if you closely look at his back, you can see he has a Decepticon insignia.
- His head being visible in vehicle mode may be a reference to his Movie-verse counterpart the first two films where his head can be seen in both forms.
- This Megatron is one of the few to actually admit that his actions are indeed wrong or evil, some others even seem to think that their causes are just. Megatron has admitted this on at least two occasions, both pertaining to Optimus's opposition to Megatron. First, "It will only be a matter of time before Optimus's innate sense of right and wrong will take over." and second, "Your Spark may be in the right place but...".