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Ever seeking an advantage in the Great War, the Decepticons set up a Biological Warfare Program, designed to kill Autobots with disease.

Transformers: Prime

Sick Mind

During the Great War, Megatron managed to develop Cybonic plague as part of the Biological Warfare Program. The plague was a success, wiping out millions on Cybertron. However, Megatron made sure to develop a cure in the event that he was infected.

Toxicity

Megatron also discovered a means of refining raw Tox-En into a devastating weapon, which may have also been a project in the Biological Warfare Program.

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